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Month: April 2011

Health Outcomes After Stopping Estrogen Alone Hormone Replacement Therapy Among Postmenopausal Women With Prior Hysterectomy

Follow up results from the Women’s Health Initiative Study Design: Women’s Health Initiative (WHI) Estrogen-Alone Trial was a double-blind, placebo-controlled randomized trial of conjugated equine estrogens (CEE) versus placebo. Study Eligibility: Postmenopausal women aged 50-79 years who had a prior hysterectomy, were not taking hormone therapy and had had an anticipated 3-year survival or more. […]

Duration of Chemotherapy for Metastatic Breast Cancer

Study Design: Systematic review of randomized controlled trials comparing shorter versus longer first-line chemotherapy duration in patients with metastatic breast cancer (MBC). Study Eligibility: Eligible trials of first-line chemotherapy in MBC patients included: trials comparing a fixed number of cycles versus continuation of the same chemotherapy (CT) until disease progression; trials comparing a fixed number […]