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Month: December 2011

NIH Scientists Find Pathway to Regulate Cancer Growth and Metastasis in Mice

In a mouse study published this month in the Journal of Clinical Investigation, scientists from the National Institute of Environmental Health Sciences (NIEHS) present a novel way to prevent tumor metastasis by eliminating the blood vessels that feed the tumor. If the production of small molecules known as epoxyeicosatrienoic acids (EETs) is stopped, cancer cells […]

SABCS 2011: Exemestane Plus Everolimus Increased Progression-Free Survival for Women With Metastatic Breast Cancer

The combination of everolimus (Afinitor) and the aromatase inhibitor exemestane (Aromasin) improved progression-free survival in women diagnosed with metastatic breast cancer, according to results of the Breast Cancer Trials of Oral Everolimus (BOLERO-2). Results of a preplanned interim analysis of phase III clinical trial were published yesterday in the New England Journal of Medicine, and […]

SABCS 2011: Dual HER2 Blockade Significantly Extends Progression-Free Survival

Results of the CLEOPATRA (CLinical Evaluation Of Pertuzumab And TRAstuzumab) trial will be presented today at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium and are also published in the New England Journal of Medicine. These findings suggest that the combination of two HER2 blocking agents, trastuzumab and pertuzumab, when used with docetaxel, prolongs […]

SABCS 2011: New Test Predicts Risk for Recurrence for Patients with DCIS

A multigene test can differentiate lower-risk and more aggressive forms of ductal carcinoma in situ (DCIS), according to results presented at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium. In a collaboration between the Eastern Cooperative Oncology Group (ECOG), North Central Cancer Treatment Group and Genomic Health, researchers used the Oncotype DX breast cancer […]

IOM Releases Report on Breast Cancer and the Environment

The Institute of Medicine (IOM) released a new report today, entitled “Breast Cancer and the Environment: A Life Course Approach.” The report, which was sponsored by Susan G. Komen for the Cure, was released during a press conference at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium. In this report, the IOM reviews the […]

SABCS 2011: Zoledronic Acid Shows Long-Term Benefit in Survivorship for Premenopausal ER-Positive Breast Cancer

Zoledronic acid and endocrine treatment improved both disease-free and overall survival in early-stage, premenopausal ER-positive breast cancer, according to study results presented at the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium. Researchers from the Austrian Breast & Colorectal Cancer Study Group (ABCSG-12) presented their results after a median of 76 months of follow-up, confirming […]