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Guide to Quality Breast Cancer Care

If you live in the United States, you can get excellent breast cancer care. But you could also get care that is wrong for you. This can happen even with good insurance and good doctors. Quality breast cancer care means getting the care that is right for you. Good breast cancer care is based on […]

PatientINFORM

KnowBreastCancer.org has partnered with patientINFORM to provide free online access to peer-reviewed medical articles. PatientINFORM is a collaborative private-sector initiative of patient health organizations, medical societies, health information professionals, and medical publishers. Through patientINFORM, patients and their family members can access the most important new research articles about diseases and treatments through the Web sites […]

HER2 Testing

Is HER2 testing accurately identifying breast cancer patients who would benefit from targeted therapy? What is HER2? HER2 (also Her-2/neu or ErbB2) stands for Human Epidermal Growth Factor Receptor 2, and is one of a family of several receptor proteins. All normal breast cells contain the HER2 gene, which gives instructions to the cell on […]

Researchers discover a rotational motion of cells that may have implications for future breast cancer research

Scientists with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory have made a discovery that may have important implications for future breast cancer research. These findings are published in the Proceedings of the National Academy of Sciences. According to the research team led by Dr. Mina Bissell, human epithelial cells in the breast and […]

Two anti-HER2 drugs may be better than one in the neoadjuvant setting

The combination of trastuzumab and lapatinib, two drugs that inhibit HER2, may be better than treatment with either agent alone in the neoadjuvant (preoperative) setting, according to results of a study published in Lancet. “This is the first demonstration that adding a second anti-HER2 therapy, lapatinib, to trastuzumab is superior to trastuzumab alone in patients […]

Glossary

Absolute risk The risk is the chance that something will happen to you during a certain period of time. It is the number of people who would have the event if 100 people were observed. It is written as a percent (%). For instance, your risk of getting a disease in the next 5 years […]

Research and Evidence

The Scientific Method The steps of the scientific method are to: Ask a Question Do Background Research Construct a Hypothesis Test a Hypothesis by Doing an Experiment Analyze Data and Draw a Conclusion Communicate Results It is important in evaluating research to think about how the hypothesis was tested – was it done in a […]

How do patients and advocates evaluate evidence?

More Questions to Ask About Evidence Where was the research done? Who did the research? Does anyone benefit financially from the research? What is missing? What do we still need to know to get a better picture of the truth? Researchers often – but don’t always – publish the results of their research in journals, […]

Where do patients and advocates find evidence?

This website, KnowBreastCancer.org, is a good place to keep up-to-date on the research looking at how breast cancer develops, how we might prevent it, and which treatments are most effective for which patients. Under the News & Research section, breast cancer studies are highlighted, summarized, and analyzed by breast cancer advocates. The Controversies section outlines […]

What is Evidence-Based Health Care?

“Evidence-based health care” means health care that is based on the best scientific research, combined with what’s important to patients, and doctors’ knowledge and experience. People are usually surprised to learn that not all medical care is based on the best evidence, but unfortunately, it’s true. Why is evidence-based health care so important? Much of […]