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Guide to Quality Breast Cancer Care

If you live in the United States, you can get excellent breast cancer care. But you could also get care that is wrong for you. This can happen even with good insurance and good doctors. Quality breast cancer care means getting the care that is right for you. Good breast cancer care is based on […]

PatientINFORM

KnowBreastCancer.org has partnered with patientINFORM to provide free online access to peer-reviewed medical articles. PatientINFORM is a collaborative private-sector initiative of patient health organizations, medical societies, health information professionals, and medical publishers. Through patientINFORM, patients and their family members can access the most important new research articles about diseases and treatments through the Web sites […]

What are the different types of research studies?

Comparative Effectiveness Research (CER) Comparative effectiveness research (CER) is a direct comparison of existing options available for treating a particular medical condition. It may compare similar treatments, such as competing drugs, or it may analyze very different interventions, such as surgery and drug therapy. It may also compare the effectiveness of how and when health […]

Relative Risk vs. Absolute Risk

We often hear news reports that something has been found to reduce the risk of breast cancer or reduce the risk of dying from breast cancer. These reports are often misleading because they use numbers representing relative risk reductions. Absolute risk reduction is what really matters, which is often much lower, and often not reported. […]

Outcome Measures or Endpoints for Clinical Trials

NBCC Says: The appropriate selection of outcome measures for cancer trials is a focus of ongoing debate. While recognizing that proper outcome selection is influenced by the specific design characteristics and resource limitations of the study, the National Breast Cancer Coalition believes that endpoints should be chosen in a manner that maximizes the usefulness and […]

Mammography Screening

Does Mammography Screening Save Lives? NBCC Position NBCC believes that there is insufficient evidence to recommend for or against universal screening mammography in any age group of women. Women who have symptoms of breast cancer such as a lump, pain or nipple discharge should seek a diagnostic mammogram. The decision to undergo screening for asymptomatic […]

Anthracyclines

Does the evidence still support their use in the first-line treatment of breast cancer? The anthracycline debate continues. In 2007, the National Breast Cancer Coalition took the position that “for the vast majority of women with breast cancer, anthracycline-based chemotherapy is no more effective and has the potential for more serious toxicities than other known […]

Ductal Carcinoma In Situ (DCIS)

Is DCIS breast cancer? How should it be treated? Controversy over Name Cancer or carcinoma implies invasiveness and DCIS is specifically not invasive. Some scientists and medical professionals are calling for the removal of “carcinoma” from the name for the disease. Nomenclature was discussed at the National Institute of Health State-of-the-Science Conference: Diagnosis and Management […]

Trastuzumab (Herceptin®)

Who will benefit and what is the optimal treatment protocol? HER2 is short for Human Epidermal Growth Factor Receptor 2 (also be called Her-2/neu or ErbB2). All normal breast cells contain copies of the HER2 gene, which gives instructions to the cell on how to make the HER2 protein. The HER2 protein, also called the […]

HER2 Testing

Is HER2 testing accurately identifying breast cancer patients who would benefit from targeted therapy? What is HER2? HER2 (also Her-2/neu or ErbB2) stands for Human Epidermal Growth Factor Receptor 2, and is one of a family of several receptor proteins. All normal breast cells contain the HER2 gene, which gives instructions to the cell on […]